What is Python's biggest disadvantage?

Most important for me are:

1) Python seems simple at first glance. There are a lot of points that always need to keep in mind. Since 2003 I used Python because it was simple. Since 2016 I use Emacs Lisp instead of Python for disposable tasks, prototypes and text processing.

2) Backward incompatibility of language and libraries more than of Java, Delphi or Emacs.

3) Dynamic typing per se. This is good for little project/team but, it is a pain in another case. I wrote a library for type checking in a big project.

4) Dynamic typing implementation makes Python slow. Even slower than Emacs Lisp. Common Lisp implementations prove that dynamically typed languages could be faster.